Researchers Discover Molecular Difference in Autistic Brains

(medicine.yale.edu)

24 points | by amichail 2 hours ago

3 comments

  • ear7h 21 minutes ago
    N=32 and

    > We want to start creating a developmental story and start understanding whether the things that we’re seeing are the root of autism or a neurological consequence of having had autism your whole life

    • jmward01 5 minutes ago
      Yeah, how many studies are done a year? Random chance is the #1 explanation with that small of a sample size. It doesn't take a degree in stats say that the next thing that needs to be done is to replicate the study a few times before making any claims or searching for any publicity. This subject is so emotional for the families involved that publicizing without more confirmation is a bit irresponsible especially if it is easy to do follow-up studies.
  • NewUser76312 29 minutes ago
    Interesting indeed. Does such a finding suggest any worthwhile easy-to-try 'treatments' that may help alleviate symptoms?

    I don't know much about the biochemistry here, I assume this is not something like GABA that can be directly supplemented. But maybe there are precursor nutritional and supplemental substances that can help these people upregulate how much of the glutamate molecule in question the body can produce.

    • wizzwizz4 27 minutes ago
      There isn't enough information to start doing that, yet. Consider: UV exposure results in sunburn, cellular damage, and increased skin pigmentation. We have medication that reduces skin pigmentation. Should we give it to people who experience chronic sunburn?
  • Hnrobert42 25 minutes ago
    It will be interesting to see if a link can be found between vaccines and lower numbers of glutamate receptors.
    • lez 3 minutes ago
      Let's be more specific: It would be interesting to see if glutamate receptor development is inhibited by intravenous administration of aluminum during early developmental stage of the infant when the brain-blood barrier is wide open.
    • gchamonlive 22 minutes ago
      It would also be interesting if there's no link to be found.